Name: Suav Florfenicol CAS 73231-34-2 Chaw tsim tshuaj paus Cov khoom Hoobkas - Customized Kev pabcuam
Brand: Rongyao
SKU: 239123979

Vim Li Cas Xaiv Peb

01/

Ntau yam kev siv
Nws txoj kev lag luam suav nrog cov kws tshuaj API thiab nruab nrab, cov tshuaj tua tsiaj API thiab nruab nrab, CDMO, thiab lwm yam. Peb tau tsim cov txheej txheem tsim khoom thiab kev tswj xyuas zoo.

02/

Ua kom tiav kev tsim nyog
Peb tau dhau US FDA daim ntawv pov thawj rau 6 lub sij hawm sib law liag thiab cov kws kho tsiaj ntawv pov thawj GMP rau 4 zaug sib law liag, thiab cov khoom raug xa tawm mus rau txawv teb chaws.

03/

Kev paub nplua nuj
Peb muaj zog R & D muaj zog thiab kev nplua nuj nyob rau hauv industrialization. Nws tau tsim kev tshawb fawb txog kev tshawb fawb thiab txuj ci kev cob qhia platform xws li National Postdoctoral Workstation, Provincial Enterprise Research Institute, thiab ua haujlwm kev lag luam-university-kev tshawb fawb kev koom tes nrog Suav Academy ntawm Sciences, Zhejiang University thiab lwm lub tsev kawm ntawv paub zoo thiab tshawb fawb hauv Suav teb.

04/

Pab neeg ua haujlwm tshaj lij
Txij li thaum nws tsim, lub tuam txhab yeej ib txwm ua raws li cov txuj ci-oriented, thiab tsim ib tug high-tech R & D pab neeg nrog PhD, xib fwb-theem senior engineers, muaj kev kawm ntawv thiab kev txawj ntse ua lub hauv paus. Peb tau ua tiav cov txheej txheem thev naus laus zis, xws li ntau tshaj 20 daim ntawv tso cai tsim khoom, suav nrog 2 daim ntawv pov thawj thoob ntiaj teb, 3 lub teb chaws cov khoom tshiab.

Lus Txhais ntawm Florfenicol CAS 73231-34-2

Florfenicol CAS 73231-34-2 yog ib hom tshuaj tua tsiaj uas tuaj yeem kho cov kab mob ua pa hauv nyuj. Nws tuaj yeem siv rau hauv aquaculture los tswj cov hnyuv sepsis hauv cov ntses thiab ua rau ntxov embryonic tuag hauv cov qe, nrog LC50 tus nqi ntawm 1.07 ug / g.

Selamectin CAS 220119-17-5

Cylamycin yog ib qho tshuaj tua kab mob uas siv tau rau hauv cov dev thiab miv. Nws yog ib qho kev sib xyaw ua ke ntawm avermectins, uas ua rau thiab / lossis txhim kho cov glutamate mediated chloride ion channel (GluCl) hauv cov pob txha, ua rau lub sijhawm ntev hyperpolarization ntawm parasitic neurons, cuam tshuam lawv cov kab mob neural ib txwm, thiab ua rau cov kab mob tuag tes tuag taw, tuag, los yog raug ntiab tawm.

Thiamphenicol CAS

Thiamphenicol CAS 15318-45-3 yog cov organic compound nrog cov tshuaj formula C12H15Cl2NO5S. Nws yog tsuas yog siv los ua tshuaj tua kab mob amide cawv thiab yog siv los kho cov kab mob plab hnyuv, obstetrics thiab gynecology, thiab cov kab mob ntawm lub ntsej muag xws li ua pa, urinary, hepatobiliary, thiab typhoid fever. Nws cov nyhuv tseem ceeb tshwj xeeb rau cov kab mob me me mus rau nruab nrab.

Fenbendazole CAS:

Fenbendazole CAS 43210-67-9 yog cov organic compound nrog cov mis mos molecular C15H13N3O2S. Nws yog cov hmoov dawb los yog yuav luag dawb, tsis muaj ntxhiab, thiab tsis qab. Cov khoom no yog soluble hauv dimethyl sulfoxide, me ntsis soluble hauv methanol, insoluble hauv dej, thiab soluble hauv glacial acetic acid. Nws yog ib qho dav-spectrum benzimidazole insecticide uas zoo tiv thaiv kab mob plab hnyuv.

Febantel CAS 58306-30-2

Febantel CAS 58306-30-2 yog ib tug deworming tus neeg sawv cev siv rau roundworm thiab tapeworm kab mob nyob rau hauv cov nqaij qaib thiab cov tsiaj nyeg.

Moxidectin CAS 113507-06-5

Moxidecin CAS 113507-06-5 yog cov tshuaj tua kab mob uas tuaj yeem siv los tiv thaiv thiab tswj cov kab mob plawv thiab kab mob sib kis.

Decoquinate CAS 18507-89-6

Decoquinate CAS 18507-89-6 yog cov tshuaj kho tsiaj uas siv los ua tshuaj tiv thaiv coccidiotic. Siv los tiv thaiv qaib coccidiosis los ntawm ntau yam coccidia (metamorphosis, rhiab, loj heev, pawg hom, toxicity, thiab brucellosis).

Fluralaner CAS 864731-61-3

Fluraliner CAS 864731-61-3 yog cov tshuaj tua kab mob thiab cov tshuaj acaricide uas cuam tshuam cov GABA thiab L-glutamate chloride channels zoo.

Dinitolmide

Dinitolmid CAS 148-01-6 yog ib qho khoom noj nqaij qaib pub siv los tiv thaiv kab mob coccidiosis.

Zoalene

Zoalene CAS 148-01-6 yog ib qho khoom noj nqaij qaib pub siv los tiv thaiv kab mob coccidiosis.

Qhov zoo ntawm Florfenicol CAS 73231-34-2

Pharmacodynamics

Florfenicol belongs rau amphenicol chav kawm ntawm broad-spectrum tshuaj tua kab mob thiab ua raws li ib tug bacteriostatic neeg sawv cev. Nws inhibits cov kab mob protein synthesis los ntawm kev khi rau 50S subunit ntawm lub ribosome, exerting nws cov teebmeem thiab ua kom pom tseeb cov kab mob muaj zog tiv thaiv ntau yam kab mob Gram-positive thiab Gram-negative. Hemolytic Pasteurella, Mannheimia haemolytica, thiab Actinobacillus pleuropneumoniae yog rhiab heev rau florfenicol.

Pharmacokinetics

Florfenicol yog nqus tau sai sai tom qab kev tswj hwm qhov ncauj, ncav cuag kev kho mob hauv cov ntshav kwv yees li ib teev tom qab, nrog cov ntshav siab tshaj plaws hauv 1 mus rau 3 teev. Lub bioavailability yog siab dua 80%. Florfenicol yog dav faib nyob rau hauv cov tsiaj lub cev thiab muaj peev xwm nkag mus rau hauv cov ntshav-hlwb barrier. Nws yog feem ntau excreted nyob rau hauv cov zis nyob rau hauv nws cov unchanged daim ntawv, nrog ib tug me me npaum li cas excreted nyob rau hauv quav.

Kev ua haujlwm ntawm Florfenicol CAS 73231-34-2

Florfenicol yog carboxamide uas yog N-dichloroacetyl derivative ntawm (1R,2S)-2-amino-3-fluoro-1-[4-(methanesulfonyl)phenyl]propan{{7} }ol. Cov tshuaj tua kab mob hluavtaws hluavtaws uas siv los kho cov kab mob bovine ua pa thiab ko taw rot; kuj siv nyob rau hauv aquaculture. Nws muaj lub luag haujlwm ua tus neeg sawv cev antimicrobial. Nws yog ib tug sulfone, ib tug thib ob cawv, ib tug organofluorine compound, ib tug organochlorine compound thiab ib tug thib ob carboxamide. Nws muaj feem xyuam nrog dichloroacetic acid.

Cov tshuaj tau pom zoo siv rau hauv nyuj nkaus xwb (hauv Tebchaws Meskas) rau kev kho mob bovine respiratory disease (BRD) txuam nrog Pasteurella haemolytica, Pasteurella multocida, thiab Haemophilus somnus. Vim tias florfenicol muaj kev ua haujlwm tawm tsam ntau yam kab mob (xws li, Mycoplasma), nws yuav pab tau rau kev kho lwm yam kab mob hauv nyuj (los yog lwm hom tsiaj) ib yam nkaus, tab sis cov ntaub ntawv tshwj xeeb yog txwv.

General Properties of Florfenicol CAS 73231-34-2

Florfenicol CAS 73231-34-2 yog ib qho tshuaj tua kab mob uas tsim cov kab mob broad-spectrum los ntawm inhibiting peptidyltransferase kev ua. Nws muaj cov kab mob dav dav, suav nrog ntau yam kab mob Gram zoo thiab tsis zoo, nrog rau mycoplasma.
Chloramphenicol yog ib qho yooj yim nruab nrab nruab nrab nitrobenzene derivative nrog iab saj. Nws yog lipid soluble heev thiab yog siv los ua lub hauv paus dawb lossis hauv ester cov ntaub ntawv (xws li, nruab nrab-tasting palmitate rau kev tswj hwm PO thiab cov dej-soluble sodium succinate rau parenteral txhaj).
Chloramphenicol yog ib qho chaw ruaj khov thiab tsis muaj kev cuam tshuam los ntawm kev kub hnyiab, yog tias pH ntawm 9 tsis tshaj. Cov pab pawg nitrophenol ntawm chloramphenicol yog hloov los ntawm ib pawg methyl sulfonyl rau thiamphenicol thiab florfenicol; florfenicol kuj muaj fluorine molecule. Cov qauv kev hloov pauv no txhim kho kev ua tau zoo, txo cov toxicity, thiab rau florfenicol, fluorine molecule txo cov kab mob tsis zoo.

Florfenicol CAS 73231-34-2 ua li cas?

Florfenicol CAS 73231-34-2 yog ib qho tshuaj tua kab mob uas tsim cov kab mob broad-spectrum los ntawm inhibiting peptidyltransferase kev ua. Nws muaj cov kab mob dav dav, suav nrog ntau yam kab mob Gram zoo thiab tsis zoo, nrog rau mycoplasma. Cov kab mob rhiab heev muaj xws li Haemophilus, Shigella dysentery, Salmonella, Escherichia coli, Pneumococcus, Influenza, Streptococcus, Staphylococcus aureus, Chlamydia, Leptospira, thiab Rickettsia hauv nyuj thiab npua. Cov khoom no tuaj yeem kis mus rau hauv cov kab mob hlwb los ntawm cov roj solubility thiab feem ntau ua rau 50s subunit ntawm 70s ribosome ntawm cov kab mob, inhibiting transpeptidase thiab cuam tshuam kev loj hlob ntawm peptidase, inhibiting tsim peptide chains, yog li tiv thaiv cov protein synthesis thiab ua tiav cov hom phiaj antibacterial. Cov khoom no muaj kev nqus sai ntawm qhov ncauj, kev faib tawm dav, ntev ib nrab-lub neej, siab ntshav tshuaj concentration, thiab lub sijhawm ntev ntawm kev kho cov ntshav.

Florfenicol CAS 73231-34-2 inhibits peptide saw txuas ntxiv los ntawm kev khi nruj rau 50S subunit ntawm cov kab mob ribosomes, cuam tshuam cov tshuaj tiv thaiv kev hloov pauv transpeptidyl transferase; Ib txhij xaiv ua yeeb yam ntawm 70S nucleosome receptors uas ua rau cov kab mob ntawm tes, hloov pauv thiab cuam tshuam nrog kev ua haujlwm ntawm peptidyltransferase, yog li ob npaug cuam tshuam nrog kev sib txuas ntawm cov kab mob protein. Cov tshuaj tua kab mob tsim cov kab mob broad-spectrum los ntawm inhibiting peptidyltransferase kev ua, nrog rau cov kab mob dav dav, suav nrog ntau yam kab mob Gram zoo, tsis zoo, thiab mycoplasma. Cov kab mob rhiab heev muaj xws li Haemophilus, Shigella dysentery, Salmonella, Escherichia coli, Pneumococcus, Influenza, Streptococcus, Staphylococcus aureus, Chlamydia, Leptospira, thiab Rickettsia hauv nyuj thiab npua.

Puas yog Florfenicol CAS 73231-34-2 Zoo ib yam li Chloramphenicol?

Florfenicol tsis pom zoo rau tib neeg siv; Txawm li cas los xij, nws muaj feem xyuam rau chloramphenicol thiab tuaj yeem xaiv rau kev tiv thaiv kab mob ntawm cov kab mob. Florfenicol tau pom tias muaj kev ua haujlwm zoo ib yam li cov tshuaj chloramphenicol, tshwj tsis yog tias nws ua haujlwm qis dua li chloramphenicol tawm tsam ntau yam kab mob sib kis, suav nrog cov kab mob chloramphenicol-resistant (16, 26, 33). Florfenicol's mechanism ntawm kev txiav txim yog hais txog kev cuam tshuam cov kab mob protein synthesis los ntawm kev khi rau 50S subunit ntawm cov kab mob ribosome thiab feem ntau suav hais tias yog bacteriostatic (12, 23, 26, 33).

Tsis yog chloramphenicol acetyltransferase (CAT), lub enzyme lub luag haujlwm rau feem ntau ntawm cov plasmid-mediated tsis kam rau chloramphenicol, los yog lub npe hu nonenzymatic chloramphenicol resistance gene (cmlA) confers resistance to florfenicol. Txog thaum tsis ntev los no, tsis muaj noob sib tham txog kev tiv thaiv fluorinated derivatives ntawm chloramphenicol lossis thiamphenicol tau paub. Txawm li cas los xij, xyoo 1996 cov kws tshawb fawb hauv Nyij Pooj tau txheeb xyuas qhov tshiab plasmid-encoded noob (pp-flo) los ntawm Photobacterium piscicida uas encoded tsis kam rau chloramphenicol thiab florfenicol. Salmonella cais tawm uas muaj cov noob floSt kuj nthuav tawm dual tsis kam rau chloramphenicol thiab florfenicol. Cov noob flo kuj tau txheeb xyuas tsis ntev los no ntawm chloramphenicol-resistant Salmonella enterica serovar Agona rho tawm los ntawm cov nqaij qaib hauv Belgium thiab florfenicol-resistant E. coli los ntawm cov nqaij qaib hauv Tebchaws Meskas.

Txoj kev tshawb fawb tam sim no muaj 48 hom tshuaj tiv thaiv kab mob tiv thaiv kab mob E. coli cais tawm ntawm cov plab hnyuv siab raum thiab xa mus rau North Dakota Veterinary Diagnostic Laboratory (ND-VDL) txij li xyoo 1997 txog 1998. Txij li thaum muaj cov ntaub ntawv txwv txog florfenicol tsis kam nyob rau hauv cov ntaub ntawv thiab zoo li tsis muaj. Hais txog E. coli, ib txoj kev tshawb fawb tau pib los txiav txim siab lub tswv yim ntawm kev tawm tsam ntawm cov kab mob E. coli cais tawm.

Ntev npaum li cas Florfenicol CAS 73231-34-2 Kev rho tawm?

Florfenicol CAS 73231-34-2 yog ib qho khoom noj khoom haus premix uas muaj florfenicol thiab tsuas yog muaj los ntawm Merck Animal Health. Lub hom phiaj tseem ceeb ntawm kev tshawb fawb teb tau ua nyob rau hauv Florfenicol CAS 73231-34-2 yog los ntsuas qhov ua tau zoo ntawm florfenicol-medicated pub rau kev tswj kev tuag ntawm ntau hom ntses uas kuaj pom muaj ntau yam kab mob uas tshwm sim los ntawm cov kab mob cuam tshuam rau florfenicol.
Florfenicol CAS 73231-34-2 cov tshuaj noj tuaj yeem yuav los ntawm cov khoom noj khoom haus hauv dej. Piv txwv li, cov kab mob txaus siab suav nrog, tab sis tsis txwv rau, (a) enteric redmouth, (b) kab mob hemorrhagic septicemia tshwm sim los ntawm Aeromonads thiab Pseudomonads, thiab (c) Aeromonas Hydrophila. Kev siv INAD tsuas yog siv rau kev siv tsis muaj npe xwb. Tag nrho cov ntawv sau npe siv yuav tsum ua raws li daim ntawv tso cai pom zoo thiab mus rau Veterinary Feed Directive.
Cov kev kho mob uas tau tso cai los tswj hwm Florfenicol CAS 73231-34-2 hauv pub yog 10 lossis 15 mg active florfenicol/kg ntses/hnub rau 10 hnub sib law liag, thiab lub sijhawm tshawb nrhiav tshem tawm cov ntses salmonids yog 15 hnub rau cov ntses dej qab zib; 15 hnub rau cov ntses dej qab ntsev ntawm 10 mg / Kg lub cev hnyav rau 10 hnub sib law liag; los yog 28 hnub rau cov ntses dej qab ntsev uas kho tau ntawm 10 - 15 mg / Kg lub cev hnyav rau 10 hnub sib law liag.

Cov lus qhia ntawm Florfenicol CAS 73231-34-2

Florfenicol tuaj yeem cuam tshuam nrog cov kab mob protein synthesis. Nws muaj qhov nqus sai thiab nthuav dav hauv lub cev; nws muaj ib nrab-lub neej ntev yam tsis muaj kev phiv xws li aplastic anemia; tsis yooj yim rau cov kab mob evolve tshuaj tiv thaiv, thiab tsis muaj kev tiv thaiv kab mob.
Florfenicol tuaj yeem siv los kho cov kab mob ntawm cov tsiaj nyeg thiab cov tsiaj hauv dej, thiab muaj txiaj ntsig zoo ntawm kev kho cov kab mob ua pa thiab kab mob hauv plab.
Nqaij qaib:Tus kab mob Escherichia coli, salmonellosis, kis kab mob rhinitis, kab mob ua pa ntev, duck plague thiab lwm yam kab mob sib xyaw ua ke los ntawm cov kab mob uas raug mob.
Tsiaj txhu:Cov kab mob sib xyaw ua ke xws li kab mob pleurisy, mob hawb pob, kab mob streptococcal, kab mob Escherichia coli, salmonellosis, kis tau pleuropneumonia, enzootic pneumonia, paratyphoid piglets daj daj dawb raws plab, kab mob edema, atrophic rhinitis, mob ntsws kis kab mob, liab dawb kab mob plab piglets tshwm sim. xws li npua, nyuj, thiab yaj.
Crab:Appendages ulcer kab mob, daj gills, rotten gill, liab ceg thiab liab fluorescent lub cev inflammatory kab mob syndrome.
vaub kib:Cov kab mob hauv caj dab liab, furunculosis, kab mob tua kab mob, kab mob ntawm daim tawv nqaij, kab mob plab hnyuv, mumps, thiab kab mob sepsis.
Qav:Cataract syndrome, kab mob ascites, sepsis, enteritis.
Ntses:Kab mob enteritis, kab mob ascites, vibriosis, Edward coli kab mob.
Eel:Debonding septicemia (cov nyhuv tshwj xeeb), kab mob Edward coli, kab mob ntawm daim tawv nqaij liab, kab mob plab hnyuv.

Dab tsi yog Spectrum ntawm Kev Ua Haujlwm ntawm Florfenicol CAS 73231-34-2?

Florfenicol yog thiamphenicol derivative nrog tib lub tswv yim ntawm kev ua raws li chloramphenicol (inhibition ntawm protein synthesis). Txawm li cas los xij, nws muaj zog dua li chloramphenicol lossis thiamphenicol, thiab tej zaum yuav muaj kab mob ntau dua li yav tas los xav tawm tsam qee yam kab mob (xws li, BRD pathogens). Florfenicol muaj ib tug dav spectrum ntawm antibacterial kev ua si uas muaj xws li tag nrho cov kab mob rhiab heev rau chloramphenicol, gram-negative bacilli, gram-positive cocci, thiab lwm yam kab mob atypical xws li mycoplasma.
Florfenicol yog lipophilic heev, uas muab siab txaus los kho cov kab mob hauv lub cev thiab hla qee qhov kev cuam tshuam ntawm lub cev (kev nkag mus thoob plaws cov ntshav-hlwb thaiv hauv cov nyuj yog 46%). Ib nrab-lub neej ntawm florfenicol yog 2-3 teev nyob rau hauv nyuj tom qab IV kev tswj hwm, tab sis nws yog ntev (18 teev) tom qab txhaj tshuaj IM, thiab 27 teev tom qab 40 mg / kg subcutaneously. Hauv cov dev, ib nrab-lub neej luv dua, nrog rau qhov muaj nuj nqis ntawm 1.1 thiab 1.2 tom qab IV thiab kev tswj hwm qhov ncauj, feem. Ib nrab-lub neej nyob rau hauv miv yog kwv yees li 4 teev thiab 7.8 teev tom qab IV thiab kev tswj qhov ncauj, feem.

Peb lub Hoobkas

Rongyao yog lub teb chaws high-tech enterprise, Zhejiang xeev science thiab technology SMEs, thiab Zhejiang xeev tshwj xeeb hauv tshwj xeeb SMEs tshiab. Peb muaj zog R & D muaj zog thiab kev nplua nuj nyob rau hauv industrialization. Nws tau tsim kev tshawb fawb txog kev tshawb fawb thiab txuj ci kev cob qhia platform xws li National Postdoctoral Workstation, Provincial Enterprise Research Institute, thiab ua haujlwm kev lag luam-university-kev tshawb fawb kev koom tes nrog Suav Academy ntawm Sciences, Zhejiang University thiab lwm lub tsev kawm ntawv paub zoo thiab tshawb fawb hauv Suav teb.

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Txij li thaum nws tsim, lub tuam txhab yeej ib txwm ua raws li cov txuj ci-oriented, thiab tsim ib tug high-tech R & D pab neeg nrog PhD, xib fwb-theem senior engineers, muaj kev kawm ntawv thiab kev txawj ntse ua lub hauv paus. Peb tau ua tiav cov txheej txheem thev naus laus zis, xws li ntau tshaj 20 daim ntawv tso cai tsim khoom, suav nrog 2 daim ntawv pov thawj thoob ntiaj teb, 3 lub teb chaws cov khoom tshiab.

Nyob rau hauv lub neej yav tom ntej, Rongyao yuav ua raws li cov qauv siab thiab cov kev cai nruj ntawm kev lag luam kws tshuaj, ua kom nrawm nrawm ntawm kev tshawb fawb thiab thev naus laus zis tshiab, thiab tsim kom muaj lub tuam txhab tshuaj kho mob thoob ntiaj teb thiab tsim kho tshiab. Peb ib txwm cog lus los tsim thiab tsim cov khoom lag luam zoo, thiab siv zog ua haujlwm tsis tu ncua los tsim kom muaj kev noj qab haus huv yav tom ntej.

Peb Daim Ntawv Pov Thawj

Qhov kawg FAQ Qhia rau Florfenicol CAS 73231-34-2

Q: Lub luag haujlwm ntawm florfenicol CAS 73231-34-2 yog dab tsi?

A: Florfenicol yog ib qho dav-spectrum bacteriostatic tshuaj tua kab mob siv tshwj xeeb hauv cov tshuaj kho tsiaj txhawm rau kho cov kab mob ntawm kev ua liaj ua teb thiab cov tsiaj hauv dej. Nws yog ib qho hluavtaws fluorinated analog ntawm thiamphenicol thiab chloramphenicol uas ua haujlwm los ntawm inhibiting ribosomal kev ua haujlwm, uas cuam tshuam cov kab mob protein synthesis thiab tau pom lub sijhawm muaj zog tiv thaiv kab mob Gram-zoo thiab tsis zoo.

Q: MOA ntawm florfenicol CAS 73231-34-2 yog dab tsi?

A: Florfenicol's mechanism ntawm kev txiav txim yog hais txog kev cuam tshuam cov kab mob protein synthesis los ntawm kev khi rau 50S subunit ntawm cov kab mob ribosome thiab feem ntau suav hais tias yog bacteriostatic. Florfenicol tsis pom zoo rau tib neeg siv; Txawm li cas los xij, nws muaj feem xyuam rau chloramphenicol thiab tuaj yeem xaiv rau kev tiv thaiv kab mob ntawm cov kab mob.

Q: Dab tsi yog spectrum ntawm kev ua ntawm florfenicol CAS 73231-34-2?

A: Florfenicol muaj qhov dav dav ntawm cov kab mob tua kab mob uas suav nrog tag nrho cov kab mob uas nkag siab rau chloramphenicol, gram-negative bacilli, gram-positive cocci, thiab lwm yam kab mob atypical xws li mycoplasma. Florfenicol yog lipophilic heev, uas muab siab txaus los kho cov kab mob hauv lub cev thiab hla qee qhov kev cuam tshuam ntawm lub cev (kev nkag mus thoob plaws cov ntshav-hlwb thaiv hauv cov nyuj yog 46%).

Q: Dab tsi yog qhov muaj pes tsawg leeg ntawm florfenicol CAS 73231-34-2?

A: Florfenicol yog carboxamide uas yog N-dichloroacetyl derivative ntawm (1R,2S)-2-amino-3-fluoro-1-[4-(methanesulfonyl)phenyl]propan{{ 7}} ua. Cov tshuaj tua kab mob hluavtaws hluavtaws uas siv los kho cov kab mob bovine ua pa thiab ko taw rot; kuj siv nyob rau hauv aquaculture. Nws muaj lub luag haujlwm ua tus neeg sawv cev antimicrobial. Nws yog ib tug sulfone, ib tug thib ob cawv, ib tug organofluorine compound, ib tug organochlorine compound thiab ib tug thib ob carboxamide. Nws muaj feem xyuam nrog dichloroacetic acid.

Q: Puas yog florfenicol CAS 73231-34-2 tib yam li chloramphenicol?

A: Florfenicol tau pom tias muaj kev ua haujlwm zoo ib yam li cov tshuaj chloramphenicol, tshwj tsis yog tias nws ua haujlwm qis dua li chloramphenicol tiv thaiv ntau yam kab mob hauv cov kab mob cais tawm, suav nrog cov kab mob chloramphenicol-resistant.

Q: Lub formulation ntawm florfenicol CAS 73231-34-2 txhaj tshuaj yog dab tsi?

A: Cov tshuaj florfenicol yog npaj los ntawm, los ntawm huab hwm coj, 5-30 qhov chaw ntawm forfenicol, 20-60 qhov chaw ntawm N, N-dimethylformamide, 10-40 qhov chaw ntawm dimethyl sulfoxide, 5-15 qhov chaw ntawm Poirot sharm F68, 5-10 qhov chaw ntawm tween-80 thiab 10-40 qhov chaw ntawm propylene glycol.

Q: Cov tshuaj tua kab mob dab tsi yog florfenicol CAS 73231-34-2?

A: Amphenicols (chloramphenicol, florfenicol, thiab thiamphenicol) yog cov tshuaj tua kab mob dav dav nrog cov qauv phenylpropanoid. Lawv muaj peev xwm tiv thaiv ntau yam kab mob Gram-positive thiab Gram-negative, nrog rau feem ntau cov kab mob anaerobic. Chloramphenicol tau siv dav rau ntau xyoo hauv kev ua tsiaj kho tsiaj ob qho tib si kho mob thiab prophylactically vim nws zoo heev thiab pheej yig los tsim.

Q: Cov txiaj ntsig tsis zoo ntawm florfenicol CAS 73231-34-2 yog dab tsi?

A: Kev cuam tshuam rau qib siab (mg / L) ntawm florfenicol tau hloov kho cov xenobiotic metabolism, antioxidant systems, thiab lub zog metabolism, ua rau hepatotoxicity, raum toxicity, immunotoxicity, kev loj hlob toxicity, reproductive toxicity, obesogenic teebmeem, thiab hormesis nyob rau hauv ntau hom tsiaj.

Q: Tib neeg puas tuaj yeem noj florfenicol CAS 73231-34-2?

A: Florfenicol yog cov tshuaj muaj pes tsawg leeg uas tau tsim los siv rau hauv cov tsiaj, tshwj xeeb yog nyuj thiab tsis yog tib neeg primates. Tsis muaj ib qho tshwj xeeb hais txog florfenicol siv rau tib neeg hauv cov ntsiab lus uas tau muab.

Q: Dab tsi yog qhov hnyav rau florfenicol CAS 73231-34-2?

A: Florfenicol yog soluble hauv cov kuab tshuaj organic xws li ethanol, DMSO, thiab dimethyl formamide. Lub solubility ntawm florfenicol nyob rau hauv cov kuab tshuaj no yog kwv yees li 14, 50, thiab 30 mg / ml, feem. Florfenicol yog me ntsis soluble hauv aqueous buffers.

Q: florfenicol CAS 73231-34-2 siv tau li cas?

A: Cov qauv ntawm florfenicol ntsig txog tshuaj. FFC tau sau tseg tias muaj txiaj ntsig zoo rau cov kab mob loj ntawm cov kab mob, ob qho tib si aerobic thiab anaerobic, suav nrog Gram-positive thiab Gram-negative, thiab kuj tawm tsam qee hom ryckettsia thiab chlamydia.

Q: Puas yog florfenicol CAS 73231-34-2 hla cov hlab ntsha hauv hlwb?

A: Florfenicol yog dav faib thoob plaws hauv lub cev thiab hla cov hlab ntsha-hlwb barrier. Kev tshem tawm yog los ntawm hepatic metabolism, thiab cov metabolites tsis ua haujlwm tau tawm hauv cov zis. Florfenicol yog ib qho kev xaiv zoo ntawm cov tshuaj tua kab mob rau kev kho cov kab mob intracellular.

Q: Lub npe tshuaj rau florfenicol CAS 73231-34-2 yog dab tsi?

A: Florfenicol (ua lag luam los ntawm Schering-Plough Animal Health nyob rau hauv lub npe lag luam Nuflor) yog fluorinated hluavtaws analog ntawm thiamphenicol, feem ntau yog siv los ua tshuaj tua kab mob hauv cov kws kho tsiaj. Raws li generic, nws yog tam sim no muaj nyob thoob ntiaj teb.

Q: Ntev npaum li cas florfenicol CAS 73231-34-2 tshem tawm?

A: Cov kev kho mob uas tau tso cai rau kev tswj hwm florfenicol CAS 73231-34-2 hauv kev pub yog 10 lossis 15 mg nquag florfenicol / kg ntses / hnub rau 10 hnub sib law liag, thiab lub sijhawm tshawb nrhiav tshem tawm rau salmonids yog 15 hnub rau cov dej tshiab-paub. finfish; 15 hnub rau cov ntses dej qab ntsev ntawm 10 mg / Kg lub cev hnyav rau 10 hnub sib law liag; los yog 28 hnub rau cov ntses dej qab ntsev uas kho tau ntawm 10 - 15 mg / Kg lub cev hnyav rau 10 hnub sib law liag.

Q: florfenicol CAS 73231-34-2 kho li cas?

A: Florfenicol yog cov tshuaj tua kab mob dav dav siv los kho cov kab mob hauv cov tsiaj hauv dej thiab ntau hom tsiaj txhu, suav nrog bovine, porcine, thiab nqaij qaib. Nws yog fluorinated analog ntawm thiamphenicol. Nws yog fluorinated analog ntawm thiamphenicol. Muaj ntau ntau yam metabolites ntawm florfenicol, suav nrog florfenicol cawv, florfenicol oxamic acid, monochloroflorfenicol, thiab florfenicol amine.

Q: Tsev neeg tshuaj dab tsi yog florfenicol CAS 73231-34-2?

A: Florfenicol (FFC) thiab thiamphenicol (TAP), uas yog amphenicols yog dav-spectrum tshuaj tua kab mob feem ntau siv nyob rau hauv veterinary los yog aquaculture xyaum. Cov tshuaj tua kab mob no khi irreversibly rau 50S ribosomal subunit tiv thaiv cov protein synthesis. TAP yog ib qho derivative ntawm chloramphenicol (CAP) nyob rau hauv uas cov pab pawg p-nitro yog hloov los ntawm ib pawg sulfomethyl whereas FFC hloov cov hydroxyl pawg ntawm C-3 site nrog ib tug fluorine atom.

Q: Cov txiaj ntsig ntawm florfenicol CAS 73231-34-2 yog dab tsi hauv cov tsiaj?

A: Cov tshuaj lom tau tshaj tawm rau cov nas yog qhov hloov pauv hauv cov kab mob hematologic thiab atrophy ntawm cov noob qes. Rau cov dev, qhov nce hauv siab hnyav tau pom. Tus dev yog hom rhiab tshaj plaws thiab NOEL yog 1 mg / kg bw / hnub.

Q: Puas yog florfenicol CAS 73231-34-2 zoo tiv thaiv E coli?

A: Florfenicol muaj cov tshuaj tua kab mob muaj zog tiv thaiv kab mob E. coli, thiab yog li nws tau ua tiav siv rau lawv txoj kev kho mob. Txawm li cas los xij, florfenicol tau dav dav hauv lub cev thiab metabolized sai; lub ntsej muag qhov ncauj qhov ncauj nrog kev tso tawm kom ruaj khov tuaj yeem ua kom cov tshuaj concentration ntawm lub hom phiaj ntawm qhov chaw, yog li ua kom lub neej ib nrab ntawm cov tshuaj hauv lub cev. Yog li, kev tsim cov tshuab xa khoom ntse rau florfenicol yuav yog qhov tseem ceeb los txhim kho cov txiaj ntsig kho mob ntawm E. coli.

Q: Dab tsi yog bioavailability ntawm florfenicol CAS 73231-34-2?

A: Lub im bioavailability thiab lub qhov ncauj bioavailability ntawm florfenicol yog 95, 98 thiab 96, 94%, feem, qhia tias florfenicol yuav luag absorbed tag nrho tom qab im thiab qhov ncauj tswj ntawm 15 thiab 30 mg / kg bw

Q: Yam tshuaj twg yog florfenicol CAS 73231-34-2?

A: Florfenicol yog broad-spectrum bacteriocidal tshuaj tua kab mob uas tawm tsam 50S ribosome ntawm cov kab mob. Nyob rau hauv nyuj, cov tshuaj yog me ntsis bioavailable (79%) tom qab txhaj tshuaj intramuscular. Cov tshuaj muaj kev faib tawm zoo rau hauv ntau cov ntaub so ntswg, suav nrog CNS.

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